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Tablet Dissolution Tester DS 14000 Smart with Piston Pump

Tablet Dissolution Tester DS 14000 SMART with Piston Pump

The dissolution tester DS 14000 Smart with piston pump is the core of our dissolution testing system. Intelligent sampling system is used where the sampling tubes are accurately moved to USP sampling position. For sample collection option of standard vials and HPLC vials is available. The needles can pierce through the septa and collect the samples so that there is no spillage.

1 million cycles for the piston pump are guaranteed with easy serviceability and maintenance. The dissolution tester comes with  21 CFR Part 11 software as a standard with LAN connectivity for data backup on network shared folders. QWERTY Keyword for entries of Sample Name, Sample Number and Identification Number for authentication. More than 1000 methods can be stored due to large memory size in the dissolution apparatus.

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Standard Features of DS 14000 SMART with Piston Pump
  • Advanced, Micro-Controller based (ARM Core): User-friendly, complies with current USP, BP, IP, JP & EP specifications.
  • Moulded water bath with 12+2 (6+1 & 6+1) vessel configuration enables comparative studies.
  • Mono shaft design with easy changeover between Apparatus I & II eliminates routine height validation as per USP.
  • Automatic stirrer 25 mm depth positioning (as per USP requirement)
  • Paddles, Baskets and Vessels are laser marked with serial numbers for traceability.
  • Automated Tablet dispenser - drops 12 dosage form at single instance.
  • Low Evaporation Lids: The conical shape low evaporation recovery lids reduces media loss during long run.
  • Integrated pre-centered lids; no manual removal or positioning of lids. This ensures automatic vessel centering and precise positioning of paddle/basket with shaft without any special tool as per pharmacopeia requirements.
  • State-of-the-art design: Easy placement and locking of vessels, the Ease-align system allows the vessels to simply slide into the place (Bionet Locking). Once placed, vessels do not float even when empty.
  • Facility to monitor Vessel temp., with an external RTD Temperature Sensor (DTS - Digital Temperature Sensor)
21 CFR Part 11 Compliance
  • Audit Trail for all activities with search facility, report generation and printing.
  • 200 and more User ID’s with alphanumeric entries of user name, password and role based privileges selection.
  • Multi-level roles with password protection,expiry & complexity
  • User authentication is performed for each and every operation done by user.
  • PDF report file can be created through print.
  • USB Printing eliminates the need of serial port to connect with instrument.
  • The user can take printout on any local or network printer as well
  • Electronic signature functionality.
  • Data Backup and Restore facility available.
  • LAN (Ethernet) connectivity for Data backup on Network shared folder
Regulatory Compliance
  • DS 14000 meets all requirements relating to validation, qualification and calibration.
  • Appropriate qualification documents (I.Q. / O.Q.) can be supplied with the instrument.
Additional Features
  • Built in validation Software
  • Facility to RINSE the entire sampling path in between sampling time - point to eliminate contamination & carryover
  • Specially developed cleaning system to clean the entire sampling path after each run
  • Facilities to perform the dissolution test using 3 buffers (Buffer changing) to cater the application of enteric coating tablets
  • Recovery Test facility to study 100% Drug Dissolution
  • Split & on-time interval
  • Disposable Syringe & Filter attachment for manual sample collection
Intelligent Sampling System
  • Automated sampling as per USP Specifications. Sampling tubes are lowered in the media only at the time of sampling and withdrawn immediately after sampling, thus no part of the assembly contributes motion, agitation or vibration.
  • Sampling tubes are accurately moved to the USP sampling position i.e. a zone mid way between the surface of media and the top of paddle/basket parameters, not less than 1 cm from the vessels wall as selected in the method.
  • 12 vessels temperature monitoring system automatically measures & records the temperature of individual vessel at specified sample points.
  • Inert PTFE Fluoropolymer Carrier Tubing
Pump System - PP 12
  • Piston Pump - PP 12 is Microprocessor controlled and is ideal for sample withdrawal from 12 channels
  • The Piston Pump - PP 12 with inert ceramic rotor overcomes all absorption issues
  • Accuracy better than 0.2 (@10mL)
  • Rinse function for reducing carryover issues
  • Surfactant Media Compatibility
  • Option of sample dilution available (not recommended before final filtration) 
Sample Collection
  • 12 X 8 X 2 sets of samples can be collected. For more sampling interval, 24 X 8 collection trays are available
  • Option of 1.5mL & 2mL HPLC vial tray is available
  • Sensor to locate proper position of tray with alarm facility for collection of sample
  • Wide mouth vial to minimise SLS spillover problem due to foaming characteristics
  • Easy positioning with respect to vials or test tube tray for easy changeover
Typical Specification



Micro Controller

Method Storage

Minimum 1000 methods with parameters

Data Storage

Available with Non-Volatile memory. More than 10,000 reports

Software Compliance

21 CFR Part 11

Temperature Range

20˚C to 55˚C

Temperature Accuracy

up to 45°C ±0.1°C & >45°C up to 55°C ±0.2°C

Temperature Resolution


Temperature Sensor

DTS - Digital Temperature Sensor

Evaporation Loss

1% (at 50 RPM / 37˚C / 1000mL / 24hrs)


7’’ high resolution display with capacitive touch screen

Paddle/Basket Shaft Stirring Speed

20 to 250 RPM (±0.5 RPM)

Sampling Time Selectivity

Fixed / programmable (Varying Intervals)

Time Interval Selectivity

In steps of 1 Minute

Sampling Volume Range

0.5 - 22.0 mL

Vessel Capacity

1000 mL

Water Bath

29 litres capacity with built-in water level sensor / front located drain tap for easy draining of the water bath

Maximum Number Of Intervals


Dissolution Process Time

1 min to 1200 hrs

Print Interface

USB / WiFi Direct enabled Printer

Data Backup Interface

USB / LAN Port

Electrical Power

110/220V AC - 50 Hz/60 Hz

Dimension (W*D*H)

115*60*70.5 cm


120 kg Approx


  • GLP Compliance:
  • QWERTY Keyboard for alphanumeric entries of Sample Name, Sample Number & Identification Number and parameters for authentication
  • Built-in Real Time Clock (RTC) for date and time on display and on printout.
  • Factory entered CUSTOMER NAME with Instrument Serial Number on report printouts make the system foolproof.
  • Non-Volatile Solid State memory storage for 1000 Test methods with parameters
  • Validation Software to validate RPM, Temperature, sampling volume & replenish volume.
  • Protects Editing, Avoids invalid entries:
  • User interactive software for ease of operation with protection against invalid entries.
  • Multilevel password protection for method editing.
  • Ease in operation:
  • Auto Start facility to continue the dissolution analysis in case of short power interruption (especially useful for long duration analysis of sustained release tablets).
  • Reports can be obtained even after Resetting / Power off / Power failure conditions.
  • Error indication helps user to trace the problem.
  • Alarms and Indications: Audible indication for ready state of instrument.
  • Wake-up Alarm: This unique feature automatically turns the bath heater ON at a predetermined time
Optional Accessories
  • Sinkers, USP 5 - Transdermal Paddle Over disk), USP 6 (Transdermal Rotating Cylinder), Intrinsic dissolution apparatus (rotating and stationary), Enhancer cell, Felodipine Basket, Sampling Cannula, Teflon coated Paddles, Gold plated Baskets
  • Dissolution test vessel : Peak Vessel 1000mL, 100mL, 150mL, 250mL & 500mL with mini paddles
  • Dissolution Qualification tool kit for mechanical calibration according to FDA
Tablet Dissolution Testers